Chioma Festus
Ignatius Ajuru University of Education, Rumuorlumeni, Rivers State, Nigeria
Title: Mixed Ligand Divalent Complexes of 2-(4,6-dimethylpyrimidin-2-ylamino)naphthalene-1,4-dione: Synthesis, investigational and hypothetical characterisation, and Biological actions.
Biography
Biography: Chioma Festus
Abstract
A new pyrimidinyl ligand, 2-(4,6-dimethylpyrimidin-2-ylamino)naphthalene-1,4-dione (HL) and its divalent heteroleptic manganese, cobalt, nickel and copper complexes have been synthesized and characterized in the light of elemental (CHN), magnetic, conductance, infrared (IR), nuclear magnetic resonance (1H- and 13C-NMR), electronic (UV-Vis), electrospray ionization mass spectrometry (ESI-MS), thermographic analysis (TGA) and molecular docking studies. The acquired results were consistent with the adoption of the chemical formula, [M(bipy)(L)(Y)]∙nH2O (where M = Mn, Co, Ni, and Cu; L = Schiff base; bipy = 2,2’-bipyridine; Y = OAc and n = 0,1) for the metallic complexes. The magnetic susceptibility measurements and low conductivity data offer proof for monomeric and neutral nature of the heteroleptic complexes. On the basis of spectral investigations and analytical data, it was manifest that the pyrimidinyl ligand acts as bidentate chelator. The divalent heteroleptic complexes were apportioned octahedral stereochemistry on the basis of electronic and magnetic susceptibility measurement data. In order to evaluate the influence of metallic ions upon chelation, both the ligands and their complexes were appraised for their antimicrobial actions against S. aureus, P. aeruginosa, E. coli, B. cereus, P. mirabilis, K. oxytoca, A. niger, A. flevus and R. Stolonifer. The antimicrobial studies presented moderate-good actions verifying their possibilities as broad-spectrum antibacterial agents. The free radical scavenging activity of newly synthesized compounds has been determined at a different concentration range by means of their interaction with the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH). Molecular docking studies on these compounds indicated significant binding attraction between the adopted drug targets and the divalent heteroleptic metallic complexes showing the potentials of the latter to be used as drugs.