Ragab Amin El-Sakka
Faculty of Engineering, Nahda University, Egypt
Title: Spectroscopic Analysis and Antimicrobial Studies for Novel Metal Oxytetracycline Drug Complexes
Biography
Biography: Ragab Amin El-Sakka
Abstract
The 1:1 and 2:1 M ratio metal complexes of new Cu(II), Co(II), Fe(III), Zn(II) and Zr(II) complexes of Oxytetracycline hydrochloride have been synthesized. Attempts have been made to ascertain their probable structures on the basis of elemental analysis, spectra (IR, Electronic) and NMR studies. The ligand forms a complexes in a molar ratio 1:1 having an empirical formula (MLSO4.nH2O) and 2:1 molar ratio having an empirical formula (M2LSO4.nH2O) where M = Cu(II), Co(II), Fe(III), Zn(II) and Zr(II), L = Oxytetracycline and n = 2 – 6. The infrared spectral data and proton magnetic resonance studies were support the postulate that Oxytetracycline reacts with metal ions as an ionic bidentate ligand through its carboxylate oxygen and the amide carbonyl oxygen. Drug compounds are biologically active, these compounds have become of interest to be studied biologically, and compared their activities against four species of bacteria (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa), and two fungal species (Aspergillus flavus and Candida albicans).